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FLASH GENE
Symbol CUL7 contributors: mct - updated : 02-07-2019
HGNC name cullin 7
HGNC id 21024
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a cullin domain, which is responsible for ROC1 binding
  • a DOC domain, which is also present in the anaphase-promoting complex
    • HOMOLOGY
    interspecies ortholog to murine Cul7
    Homologene
    FAMILY
  • cullin family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,Golgi
    text
  • localizes to the Golgi complex in brain neurons
    • basic FUNCTION
  • involved in a ubiquitin-dependent proteolysis pathway
  • mediating the ubiquitination and subsequent proteosomal degradation of target proteins
  • playing a role in the degradation of proteins involved in endothelial proliferation and/or differentiation
  • promoting cell growth through, in part, antagonizing the function of TP53
  • functional inhibitor of Myc-induced apoptosis (new oncogene that cooperates with Myc in transformation by blocking Myc-induced apoptosis in a TP53-dependent manner)
  • key role in targeting IRS1 for degradation, a process that may contribute to the regulation of cellular senescence
  • OBSL1-regulated CUL7/FBXW8 ubiquitin signaling mechanism that orchestrates the morphogenesis of the Golgi apparatus and patterning of dendrites
    • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with FBXW8 (FBXW8-CUL7 complex plays a significant role in growth control)
  • (CUL7) E3 ubiquitin ligase complex containing the FBXW8-substrate-targeting subunit, SKP1, and the RBX1 RING finger protein
  • OBSL1 forms a physical complex with the scaffold protein CUL7 and thereby localizes CUL7 at the Golgi apparatus
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with the Skp1/Fbx29 complex
  • IRS1, a critical mediator of the insulin/insulin-like growth factor 1 signaling, as a proteolytic target of the CUL7 E3 ligase
  • physical interaction of OBSL1 with both CUL7 and CCDC8 and its potential role in the regulation of CUL7 expression suggesting all three proteins are members of the same growth-regulatory pathway
  • CD36 functioned through ubiquitination-dependent binding to IRS1 and inhibiting its interaction with CUL7, a key component of the multisubunit cullin-RING E3 ubiquitin ligase complex
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) GFS
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS