basic FUNCTION
| involved in a ubiquitin-dependent proteolysis pathway |
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mediating the ubiquitination and subsequent proteosomal degradation of target proteins |
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playing a role in the degradation of proteins involved in endothelial proliferation and/or differentiation |
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promoting cell growth through, in part, antagonizing the function of TP53 |
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functional inhibitor of Myc-induced apoptosis (new oncogene that cooperates with Myc in transformation by blocking Myc-induced apoptosis in a TP53-dependent manner) |
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key role in targeting IRS1 for degradation, a process that may contribute to the regulation of cellular senescence |
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OBSL1-regulated CUL7/FBXW8 ubiquitin signaling mechanism that orchestrates the morphogenesis of the Golgi apparatus and patterning of dendrites |