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FLASH GENE
Symbol CUL7 contributors: mct - updated : 02-07-2019
HGNC name cullin 7
HGNC id 21024
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveintestinesmall intestine  highly
Endocrinepancreas    
Reproductivefemale systemovary  highly
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Connectivebone   
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
not specificchondrocyte
Skeletonosteoblast
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text kidney, brain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a cullin domain, which is responsible for ROC1 binding
  • a DOC domain, which is also present in the anaphase-promoting complex
  • HOMOLOGY
    interspecies ortholog to murine Cul7
    Homologene
    FAMILY
  • cullin family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,Golgi
    text
  • localizes to the Golgi complex in brain neurons
  • basic FUNCTION
  • involved in a ubiquitin-dependent proteolysis pathway
  • mediating the ubiquitination and subsequent proteosomal degradation of target proteins
  • playing a role in the degradation of proteins involved in endothelial proliferation and/or differentiation
  • promoting cell growth through, in part, antagonizing the function of TP53
  • functional inhibitor of Myc-induced apoptosis (new oncogene that cooperates with Myc in transformation by blocking Myc-induced apoptosis in a TP53-dependent manner)
  • key role in targeting IRS1 for degradation, a process that may contribute to the regulation of cellular senescence
  • OBSL1-regulated CUL7/FBXW8 ubiquitin signaling mechanism that orchestrates the morphogenesis of the Golgi apparatus and patterning of dendrites
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with FBXW8 (FBXW8-CUL7 complex plays a significant role in growth control)
  • (CUL7) E3 ubiquitin ligase complex containing the FBXW8-substrate-targeting subunit, SKP1, and the RBX1 RING finger protein
  • OBSL1 forms a physical complex with the scaffold protein CUL7 and thereby localizes CUL7 at the Golgi apparatus
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with the Skp1/Fbx29 complex
  • IRS1, a critical mediator of the insulin/insulin-like growth factor 1 signaling, as a proteolytic target of the CUL7 E3 ligase
  • physical interaction of OBSL1 with both CUL7 and CCDC8 and its potential role in the regulation of CUL7 expression suggesting all three proteins are members of the same growth-regulatory pathway
  • CD36 functioned through ubiquitination-dependent binding to IRS1 and inhibiting its interaction with CUL7, a key component of the multisubunit cullin-RING E3 ubiquitin ligase complex
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) GFS
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS