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FLASH GENE
Symbol IFI35 contributors: mct - updated : 21-10-2015
HGNC name interferon-induced protein 35
HGNC id 5399
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
zipper motif
mono polymer homomer , heteromer , dimer
HOMOLOGY
intraspecies homolog to NMI
Homologene
FAMILY NMI family
CATEGORY immunity/defense , transcription factor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
intracellular,nucleus
basic FUNCTION
  • may represent a novel pathway of interferon-mediated antiviral activity in host organisms that plays a role in the maintenance of foamy virus latency
  • plays important roles in antiviral defense and the progression of some skin cancer diseases
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component a component of complex with NMI,which is effected by the phosphorylation of IFI35 and with BATF
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • IFI35 and its homologue NMI are two novel PLEKHO1 interacting partners
  • IRF1 and IRF2 could bind to IFP35 promoter and upregulate endogenous IFP35 protein level
  • TRIM21 is an interacting partner of IFI35 and NMI, and TRIM21 appears to be a critical regulator of the functions of the NMI-IFI35 complex
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS