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FLASH GENE

Symbol

IFI35

contributors: mct - updated : 21-10-2015

HGNC name	interferon-induced protein 35
HGNC id	5399

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_005533 7 - 1235 NP_005524 - 288 - 2002 11911807

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen         Cardiovascular heart         Digestive esophagus       highly   salivary gland       highly Endocrine pancreas         Reproductive male system prostate       Skin/Tegument skin       highly Urinary kidney         Visual eye uvea

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial barrier/lining retinal pigment epithelium (RPE)

cells

System Cell Pubmed Species Stage Rna symbol   epithelial cell   fibroblast Lymphoid/Immune macrophage

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

zipper motif

mono polymer

homomer , heteromer , dimer

HOMOLOGY

intraspecies

homolog to NMI

Homologene

FAMILY

NMI family

CATEGORY

immunity/defense , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus

basic FUNCTION	may represent a novel pathway of interferon-mediated antiviral activity in host organisms that plays a role in the maintenance of foamy virus latency
	plays important roles in antiviral defense and the progression of some skin cancer diseases

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

a component of complex with NMI,which is effected by the phosphorylation of IFI35 and with BATF

INTERACTION

DNA

RNA

small molecule

protein	IFI35 and its homologue NMI are two novel PLEKHO1 interacting partners
	IRF1 and IRF2 could bind to IFP35 promoter and upregulate endogenous IFP35 protein level
	TRIM21 is an interacting partner of IFI35 and NMI, and TRIM21 appears to be a critical regulator of the functions of the NMI-IFI35 complex

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS