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FLASH GENE
Symbol COPS8 contributors: mct/npt - updated : 11/09/2008
HGNC name COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis)
HGNC id 24335
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one PCI domain
    • HOMOLOGY
    Homologene
    FAMILY
  • CSN8 family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • signalosome regulating differentially the ubiquitin ligase activity in the DDB2 and CKN1 complexes in response to DNA damage
  • increases the efficiency of von Hippel-Lindau protein ubiquitin ligase-mediated hypoxia-inducible factor-alpha ubiquitination
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS