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FLASH GENE
Symbol COPS8 contributors: mct/npt - updated : 11/09/2008
HGNC name COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis)
HGNC id 24335
DNA
TYPE functioning gene
STRUCTURE 13.40 kb     8 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 2279 23 209 - Groisman, Miyauchi (2008)
9 - 2339 - 160 - Groisman, Miyauchi (2008)
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Endocrinepancreas   highly
Lymphoid/Immunethymus    
Nervousbrain    
Respiratorylung   highly
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text spleen
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one PCI domain
  • HOMOLOGY
    Homologene
    FAMILY
  • CSN8 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • signalosome regulating differentially the ubiquitin ligase activity in the DDB2 and CKN1 complexes in response to DNA damage
  • increases the efficiency of von Hippel-Lindau protein ubiquitin ligase-mediated hypoxia-inducible factor-alpha ubiquitination
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS