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FLASH GENE
Symbol NDUFS7 contributors: mct - updated : 15-01-2020
HGNC name NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase)
HGNC id 7714
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
secondary structure forty subunits
HOMOLOGY
interspecies homolog to C.elegans W10D5.2
Homologene
FAMILY complex I 20 kDa subunit family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,mitochondria,inner
basic FUNCTION
  • having NADH dehydrogenase (ubiquinone) activity
  • playing a role in role in the biogenesis of complex I
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component of the complex I multi-subunit enzyme of the oxidative phosphorylation (OXPHOS)
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds 1 4Fe-4S cluster
  • NDUFAF5 catalyzes the introduction of a hydroxyl group, into Arg-73 in the NDUFS7 subunit of human complex I
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) NDUFS7
    related resource MITOP database
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS