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FLASH GENE

Symbol

NDUFS7

contributors: mct - updated : 15-01-2020

HGNC name	NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase)
HGNC id	7714

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine     highly   salivary gland       highly Nervous brain       highly Visual eye       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal   highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

secondary structure

forty subunits

HOMOLOGY

interspecies

homolog to C.elegans W10D5.2

Homologene

FAMILY

complex I 20 kDa subunit family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria,inner

basic FUNCTION	having NADH dehydrogenase (ubiquinone) activity
	playing a role in role in the biogenesis of complex I

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

component of the complex I multi-subunit enzyme of the oxidative phosphorylation (OXPHOS)

INTERACTION

DNA

RNA

small molecule

protein	binds 1 4Fe-4S cluster
	NDUFAF5 catalyzes the introduction of a hydroxyl group, into Arg-73 in the NDUFS7 subunit of human complex I

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

NDUFS7

related resource

MITOP database

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS