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FLASH GENE
Symbol A1CF contributors: mlc - updated : 10-01-2011
HGNC name APOBEC1 complementation factor
HGNC id 24086
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal 320 AAs retained RNA-binding selectivity and supported complementation of editing activity and in addition demonstrate a novel RNA-bridged multimerization of A1CF
  • three non-identical RNA recognition motifs (RRM) domains
  • a 41-residue motif (ANS) in the auxiliary domain functioning as an authentic nuclear localization signal
    • secondary structure RRMs are a well-described structural fold consisting of 4 antiparallel beta-strands packed by two alpha helices
    HOMOLOGY
    interspecies homolog to rattus Acf (94.2 pc)
    Homologene
    FAMILY
  • hnRNP R family of RNA-binding proteins
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,nucleus,chromatin/chromosome,heterochromosome
    text
  • predominantly localized to heterochromatin
  • found at the outer surface of the endoplasmic reticulum
    • basic FUNCTION
  • may be involved in RNA editing or RNA processing events
  • regulating nucleocytoplasmic import and shuttling
  • being responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA
  • being probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target cytosine
  • protecting the edited APOB mRNA from nonsense-mediated decay
  • RNA-binding protein that facilitated site-specific targeting of apoB mRNA for C to U editing
    • CELLULAR PROCESS nucleotide
    PHYSIOLOGICAL PROCESS
    text
  • mRNA processing and editing
    • PATHWAY
    metabolism
    signaling
    a component
  • essential component of the apolipoprotein B mRNA editing enzyme complex
  • interacting with KHSRP/KRSP which may confer stability on the editing complex
    • INTERACTION
    DNA
    RNA
  • binding to APOB mRNA
  • binding to single-stranded RNA
    • small molecule
    protein
  • binding to the protein carrier, transportin 2
  • interacting with the nuclear import protein TNPO2/TRN2 which may be responsible for its transport into the nucleus
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS