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FLASH GENE

Symbol

A1CF

contributors: mlc - updated : 10-01-2011

HGNC name	APOBEC1 complementation factor
HGNC id	24086

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine     moderately   liver       highly   stomach       highly Reproductive male system prostate       Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective       moderately

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N-terminal 320 AAs retained RNA-binding selectivity and supported complementation of editing activity and in addition demonstrate a novel RNA-bridged multimerization of A1CF
	three non-identical RNA recognition motifs (RRM) domains
	a 41-residue motif (ANS) in the auxiliary domain functioning as an authentic nuclear localization signal

secondary structure

RRMs are a well-described structural fold consisting of 4 antiparallel beta-strands packed by two alpha helices

HOMOLOGY

interspecies

homolog to rattus Acf (94.2 pc)

Homologene

FAMILY

hnRNP R family of RNA-binding proteins

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
	intracellular,nucleus,chromatin/chromosome,heterochromosome
text	predominantly localized to heterochromatin
	found at the outer surface of the endoplasmic reticulum

basic FUNCTION	may be involved in RNA editing or RNA processing events
	regulating nucleocytoplasmic import and shuttling
	being responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA
	being probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target cytosine
	protecting the edited APOB mRNA from nonsense-mediated decay
	RNA-binding protein that facilitated site-specific targeting of apoB mRNA for C to U editing

CELLULAR PROCESS

nucleotide

PHYSIOLOGICAL PROCESS

text	mRNA processing and editing

PATHWAY

metabolism

signaling

a component	essential component of the apolipoprotein B mRNA editing enzyme complex
	interacting with KHSRP/KRSP which may confer stability on the editing complex

INTERACTION

DNA

RNA	binding to APOB mRNA
	binding to single-stranded RNA

small molecule

protein	binding to the protein carrier, transportin 2
	interacting with the nuclear import protein TNPO2/TRN2 which may be responsible for its transport into the nucleus

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS