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FLASH GENE
Symbol SASH1 contributors: mct/npt - updated : 15/102008
HGNC name SAM and SH3 domain containing 1
HGNC id 19182
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two sam (sterile alpha motif) domain
  • one sh3 domain
    • HOMOLOGY
    interspecies ortholog to murine Sash1
    Homologene
    FAMILY
  • SH3/SAM adapter molecules family
    • CATEGORY signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • tumor suppressor gene possibly involved in tumorigenesis of breast and other solid cancers
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in breast cancer
    tumoral     --low  
    correlated with the formation of metachronous distant metastasis in colorectal cancer, and multivariate analysis identified (downregulation is an independent negative prognostic parameter for patient survival)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS