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FLASH GENE
Symbol SASH1 contributors: mct/npt - updated : 15/102008
HGNC name SAM and SH3 domain containing 1
HGNC id 19182
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
20 - 7709 136.5 1247 - Rimkus (2006)
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen   highly
Cardiovascularheart   predominantly
Digestiveliver   predominantly
Endocrinepancreas   highly
Nervousbrain   predominantly
Reproductivefemale systemovary  predominantly
 male systemtestis  highly
Respiratorylung   predominantly
Urinarykidney   predominantly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Lymphoid    
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticmature hematopoietic
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two sam (sterile alpha motif) domain
  • one sh3 domain
  • HOMOLOGY
    interspecies ortholog to murine Sash1
    Homologene
    FAMILY
  • SH3/SAM adapter molecules family
  • CATEGORY signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • tumor suppressor gene possibly involved in tumorigenesis of breast and other solid cancers
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in breast cancer
    tumoral     --low  
    correlated with the formation of metachronous distant metastasis in colorectal cancer, and multivariate analysis identified (downregulation is an independent negative prognostic parameter for patient survival)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS