| basic FUNCTION
| playing a role in B lineage commitment and/or modulation of signal through the B cell receptor |
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functions as a coreceptor for lymphocyte activation and/or adhesion via extravellular and cytoplasmic domains |
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in response to inflammation-associated stimuli, the inducible receptor Slamf8 negatively regulates inflammatory responses  |
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natural killer T (NKT) cells and innate CD8(+) T cell development can be regulated in a SAP-dependent and -independent fashion by SLAMF receptors, in which SLAMF1, SLAMF6, and SLAMF8 affect development of NKT cells, and CD84, SLAMF7, and SLAMF8 affect the development of innate CD8(+) T cells |
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is a negative regulator of ROS in response to Gram+ and Gram- bacteria |
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SLAMF1 and SLAMF8 govern ROS-dependent innate immune responses of myeloid cells, thus modulating migration of these cells during inflammation in an opposing manner |
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