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FLASH GENE
Symbol SLAMF8 contributors: mct - updated : 16-02-2016
HGNC name SLAM family member 8
HGNC id 21391
Location 1q23.2      Physical location : 159.796.478 - 159.807.281
Synonym name
  • BCM-like membrane protein precursor
  • B lymphocyte activator macrophage expressed
    • Synonym symbol(s) SBBI42, BLAME, CD353
    DNA
    TYPE functioning gene
    STRUCTURE 10.85 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 3316
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
    Lymphoid/Immunelymph node   highly
     thymus    
    Reproductivefemale systembreastmammary gland  
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmonocyte
    Lymphoid/Immunedendritic cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one immunoglobulin-like c2-type domain
  • one immunoglobulin-like v-type domain
    • HOMOLOGY
    Homologene
    FAMILY CD2 family of cell surface proteins
    CATEGORY receptor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text attached to the membrane by a GPI-anchor
    basic FUNCTION
  • playing a role in B lineage commitment and/or modulation of signal through the B cell receptor
  • functions as a coreceptor for lymphocyte activation and/or adhesion via extravellular and cytoplasmic domains
  • in response to inflammation-associated stimuli, the inducible receptor Slamf8 negatively regulates inflammatory responses
  • natural killer T (NKT) cells and innate CD8(+) T cell development can be regulated in a SAP-dependent and -independent fashion by SLAMF receptors, in which SLAMF1, SLAMF6, and SLAMF8 affect development of NKT cells, and CD84, SLAMF7, and SLAMF8 affect the development of innate CD8(+) T cells
  • is a negative regulator of ROS in response to Gram+ and Gram- bacteria
  • SLAMF1 and SLAMF8 govern ROS-dependent innate immune responses of myeloid cells, thus modulating migration of these cells during inflammation in an opposing manner
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by interferon gamma
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS