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FLASH GENE
Symbol ANGEL1 contributors: mct - updated : 26-10-2018
HGNC name angel homolog 1 (Drosophila)
HGNC id 19961
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • C-terminal endo-exonuclease-phosphatase domain (EEP) found in CCR4 or Nocturnin proteins, with the EIF4E-binding motif only found in the C-terminal domain of ANGEL1 sequences
    • HOMOLOGY
    intraspecies paralog to ANGEL2
    Homologene
    FAMILY CCR4 deadenylase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text
  • is mainly distributed in the endoplasmic reticulum and Golgi apparatus
    • basic FUNCTION
  • ANGEL1 and ANGEL2 are predicted to function as deadenylases, but there are some key differences between these proteins and the other CCR4 family members
  • appeared as a doublet, probably owing to a post-transcriptional process that remains to be identified
  • the formation of the ANGEL1/EIF4E complex is independent of the MTOR signaling pathway and its downstream target EIF4EBP1
  • is not broadly distributed in the cell, but rather is concentrated in the endoplasmic reticulum and/or Golgi apparatus
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ANGEL1 has been shown to interact with CHAF1A, which has deadenylase activity, suggesting that ANGEL1 may recruit CHAF1A in EIF4E complexes
  • EIF4E localization is independent of ANGEL1
  • ANGEL1, is a partner of EIF4E
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS