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FLASH GENE

Symbol

ANGEL1

contributors: mct - updated : 26-10-2018

HGNC name	angel homolog 1 (Drosophila)
HGNC id	19961

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Digestive liver         Endocrine pancreas         Nervous brain         Reproductive female system ovary         male system testis     highly Respiratory lung           respiratory tract larynx     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

C-terminal endo-exonuclease-phosphatase domain (EEP) found in CCR4 or Nocturnin proteins, with the EIF4E-binding motif only found in the C-terminal domain of ANGEL1 sequences

HOMOLOGY

intraspecies

paralog to ANGEL2

Homologene

FAMILY

CCR4 deadenylase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,endoplasmic reticulum
	intracellular,cytoplasm,organelle,Golgi
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus
text	is mainly distributed in the endoplasmic reticulum and Golgi apparatus

basic FUNCTION	ANGEL1 and ANGEL2 are predicted to function as deadenylases, but there are some key differences between these proteins and the other CCR4 family members
	appeared as a doublet, probably owing to a post-transcriptional process that remains to be identified
	the formation of the ANGEL1/EIF4E complex is independent of the MTOR signaling pathway and its downstream target EIF4EBP1
	is not broadly distributed in the cell, but rather is concentrated in the endoplasmic reticulum and/or Golgi apparatus

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	ANGEL1 has been shown to interact with CHAF1A, which has deadenylase activity, suggesting that ANGEL1 may recruit CHAF1A in EIF4E complexes
	EIF4E localization is independent of ANGEL1
	ANGEL1, is a partner of EIF4E

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS