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FLASH GENE
Symbol CD300C contributors: mct - updated : 12 -11-201
HGNC name CD300c antigen
HGNC id 19320
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an immunoglobulin-like v-type domain
  • a short cytoplasmic tail in combination with a transmembrane region bearing a negatively charged AA, which theoretically would avoid transmembrane charge complementation with the known adaptor polypeptides
  • an ER retrieval motif within its 12-AA-long cytoplasmic tail
    • HOMOLOGY
    intraspecies homolog to highly homologous with CD300A
    Homologene
    FAMILY CD300 family of paired immune receptors
    CATEGORY immunity/defense , antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • CD300A and CD300C are indistinguishable on the surface of NK cells 1)
  • CD300A/CD300C receptors are differentially expressed on human TH1 and TH17 cells and their ligation is capable of modulating TCR mediated signals
  • would regulate the expression of other CD300 molecules and the composition of CD300 complexes on the cell surface
  • activating receptor expressed on monocytes and having a potential role in inflammatory responses
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CD300C signaling is partially mediated by a direct association with the immune receptor tyrosine-based activation motif-bearing adaptor FCER1G
  • CD300LD recruited FCER1G as efficiently as CD300C
  • specific engagement of CD300C led to FCER1G-dependent activation of mast cells and monocytes
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS