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FLASH GENE

Symbol

CD300C

contributors: mct - updated : 12 -11-201

HGNC name	CD300c antigen
HGNC id	19320

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive male system prostate       Respiratory lung         Visual eye uvea choroid

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial barrier/lining retinal pigment epithelium (RPE)

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic leukocyte Blood/Hematopoietic monocyte Homo sapiens not specific mast cell Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text

eye

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an immunoglobulin-like v-type domain
	a short cytoplasmic tail in combination with a transmembrane region bearing a negatively charged AA, which theoretically would avoid transmembrane charge complementation with the known adaptor polypeptides
	an ER retrieval motif within its 12-AA-long cytoplasmic tail

HOMOLOGY

intraspecies

homolog to highly homologous with CD300A

Homologene

FAMILY

CD300 family of paired immune receptors

CATEGORY

immunity/defense , antigen

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	CD300A and CD300C are indistinguishable on the surface of NK cells 1)
	CD300A/CD300C receptors are differentially expressed on human TH1 and TH17 cells and their ligation is capable of modulating TCR mediated signals
	would regulate the expression of other CD300 molecules and the composition of CD300 complexes on the cell surface
	activating receptor expressed on monocytes and having a potential role in inflammatory responses

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	CD300C signaling is partially mediated by a direct association with the immune receptor tyrosine-based activation motif-bearing adaptor FCER1G
	CD300LD recruited FCER1G as efficiently as CD300C
	specific engagement of CD300C led to FCER1G-dependent activation of mast cells and monocytes

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS