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FLASH GENE
Symbol MIR155 contributors: mct - updated : 08-06-2011
HGNC name microRNA 155
HGNC id 31542
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
HOMOLOGY
Homologene
FAMILY
CATEGORY
SUBCELLULAR LOCALIZATION
CELLULAR PROCESS
PHYSIOLOGICAL PROCESS
PATHWAY
metabolism
signaling
a component
INTERACTION
DNA
RNA
small molecule
protein
cell & other
REGULATION
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
significantly correlated with lymph node metastases
tumoral     --over  
significantly associated with venous invasion, liver metastasis and tumor stage
constitutional     --over  
altered the cellular responses to TGFB by changing the expression of a set of genes that is involved in inflammation, fibrosis, and angiogenesis
constitutional     --over  
inflammatory cytokines increase MIR155 expression in human retinal pigment epithelial cells by activating the JAK/STAT signaling pathway, in age-related macular degeneration
tumoral     --over  
in breast cancer cells leads to constitutive activation of signal transducer and activator of transcription 3 (STAT3) through the Janus-activated kinase (JAK) pathway, and stimulation of breast cancer cells
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • increases in miR21 and miR155 expression may represent effective biomarkers for the prediction of a poor prognosis in colorectal cancer
  • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    miR-155 may be a potential target in breast cancer therapy
    ANIMAL & CELL MODELS