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FLASH GENE
Symbol MIR155 contributors: mct - updated : 08-06-2011
HGNC name microRNA 155
HGNC id 31542
Location 21q21      Physical location : 26.946.291 - 26.946.356
Synonym name
  • activated by promoter insertion at a common retroviral integration site in B cell lymphomas induced by avian leukosis virus
  • Synonym symbol(s) BIC, hsa-mir-155, MIRN155
    DNA
    TYPE small rna
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type untranslated
    EXPRESSION
    Rna function
  • non coding RNA
  • involved in modulation of inactivation of mismatch repair as a mechanism of cancer pathogenesis
  • involved in the regulation of the immune response in myeloid cells
  • role for MIR-155 in directly repressing SMAD2 expression
  • important role for MIR-155 in modulating the cellular response to TGFB with possible implications in several human diseases where homeostasis of TGFB might be altered
  • is one of the primary miRNAs that significantly represses the expression of MEF2A
  • important regulator of MEF2A expression, having a function in muscle gene expression and myogenic differentiation
  • BRCA1 epigenetically represses MIR155 expression via its association with HDAC2, which deacetylates histones H2A and H3 on the MIR155 promoter
  • Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
     thymus    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY
    SUBCELLULAR LOCALIZATION
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    significantly correlated with lymph node metastases
    tumoral     --over  
    significantly associated with venous invasion, liver metastasis and tumor stage
    constitutional     --over  
    altered the cellular responses to TGFB by changing the expression of a set of genes that is involved in inflammation, fibrosis, and angiogenesis
    constitutional     --over  
    inflammatory cytokines increase MIR155 expression in human retinal pigment epithelial cells by activating the JAK/STAT signaling pathway, in age-related macular degeneration
    tumoral     --over  
    in breast cancer cells leads to constitutive activation of signal transducer and activator of transcription 3 (STAT3) through the Janus-activated kinase (JAK) pathway, and stimulation of breast cancer cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • increases in miR21 and miR155 expression may represent effective biomarkers for the prediction of a poor prognosis in colorectal cancer
  • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    miR-155 may be a potential target in breast cancer therapy
    ANIMAL & CELL MODELS