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FLASH GENE
Symbol CADM4 contributors: mct/ - updated : 24-03-2013
HGNC name cell adhesion molecule 4
HGNC id 30825
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two ig-like c2-type (immunoglobulin-like) domains
  • one ig-like v-type (immunoglobulin-like) domain
  • a single transmembrane domain
  • a short cytosolic tail with a protein 4.1 interaction sequence and a PDZ type II motif
    • HOMOLOGY
    interspecies ortholog to murine Igsf4c
    intraspecies homolog to NECL1
    Homologene
    FAMILY
  • TSLC1 gene family
  • nectin-like family
  • CADM-family protein
    • CATEGORY adhesion , tumor suppressor , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • required for normal tracheal development and maintenance of the trans-epithelial diffusion barrier
  • acting as a homophilic cell-adhesion molecule
  • playing a role in early neuronal differentiation and axon outgrowth
  • functioning as adhesion molecule
  • playing an important role for mediating axon-glia contact during myelination in peripheral nerves
  • mediates the Schwann cell-axon interactions necessary for myelination
  • could play an important role in cell-cell interaction as well as in tumor suppression
  • key role for CADM4 in initiating peripheral nervous system myelination and the Necl proteins are mediators of axo-glial interactions along the internode
  • with CADM3, suppress the growth and tumorigenic ability of colon cancer cells
  • cascade of CADM4 and EPB41L3 plays an important role in normal cell adhesion of the proximal tubules
  • is a novel tumor suppressor candidate in renal clear cell carcinoma acting with its binding partner EPB41L3
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • glial binding partner for axonal CADM3
  • interacting with EPB41L2 (plays a role in spermatogenesis by mediating cell-cell adhesion between spermatogenic and Sertoli cells through its interaction with CADM4 on Sertoli cells)
  • MAG together with other adhesion molecules such as CADM4 is important in sustaining axonal integrity
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       loss of function
    in glioma and prostate cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS