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FLASH GENE
Symbol CADM4 contributors: mct/ - updated : 24-03-2013
HGNC name cell adhesion molecule 4
HGNC id 30825
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestine  highly Homo sapiens
 intestinesmall intestine  highly Homo sapiens
Nervousbrain   highly
Reproductivefemale systembreastmammary gland highly
Urinarykidneytubuleconvoluted tubuleproximal tubulehighly Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
NervousSchawnn cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two ig-like c2-type (immunoglobulin-like) domains
  • one ig-like v-type (immunoglobulin-like) domain
  • a single transmembrane domain
  • a short cytosolic tail with a protein 4.1 interaction sequence and a PDZ type II motif
  • HOMOLOGY
    interspecies ortholog to murine Igsf4c
    intraspecies homolog to NECL1
    Homologene
    FAMILY
  • TSLC1 gene family
  • nectin-like family
  • CADM-family protein
  • CATEGORY adhesion , tumor suppressor , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • required for normal tracheal development and maintenance of the trans-epithelial diffusion barrier
  • acting as a homophilic cell-adhesion molecule
  • playing a role in early neuronal differentiation and axon outgrowth
  • functioning as adhesion molecule
  • playing an important role for mediating axon-glia contact during myelination in peripheral nerves
  • mediates the Schwann cell-axon interactions necessary for myelination
  • could play an important role in cell-cell interaction as well as in tumor suppression
  • key role for CADM4 in initiating peripheral nervous system myelination and the Necl proteins are mediators of axo-glial interactions along the internode
  • with CADM3, suppress the growth and tumorigenic ability of colon cancer cells
  • cascade of CADM4 and EPB41L3 plays an important role in normal cell adhesion of the proximal tubules
  • is a novel tumor suppressor candidate in renal clear cell carcinoma acting with its binding partner EPB41L3
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • glial binding partner for axonal CADM3
  • interacting with EPB41L2 (plays a role in spermatogenesis by mediating cell-cell adhesion between spermatogenic and Sertoli cells through its interaction with CADM4 on Sertoli cells)
  • MAG together with other adhesion molecules such as CADM4 is important in sustaining axonal integrity
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       loss of function
    in glioma and prostate cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS