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FLASH GENE
Symbol USP2 contributors: mct - updated : 12-01-2013
HGNC name ubiquitin specific protease 2
HGNC id 12618
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
intracellular,nucleus
intracellular,nuclear envelope
basic FUNCTION
  • having ubiquitin thiolesterase activity
  • having a direct proapoptotic activity additionally tightening the connection between apoptosis and the ubiquitin-proteasome system
  • implicated as a novel positive regulator of TNF-induced NFKB signaling and show that its expression is altered in tumor cells
  • de-ubiquitinylates and stabilizes target proteins, is rhythmically expressed in multiple tissues including the SCN
  • potentially mediates circadian disruption by suppressing the CRY1 degradation during inflammation
  • role for the rhythmically-expressed deubiquitinating enzyme ubiquitin specific peptidase 2 (USP2) in clock function
  • CELLULAR PROCESS cell life, cell death/apoptosis
    protein, degradation
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • new core component of the clock machinery and potential role for deubiquitination in the regulation of the circadian clock, both at the level of the core pacemaker and its response to external cues
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • STUB1 and USP2 show antagonistic functions in the control of AIFM1-mediated cell death, and implicate the role of the enzymes as a switch for cells to live or die under stresses that cause truncated AIFM1 release
  • mediates mitotic progression by regulating the stability of Aurora-A
  • interacts with CRY1 and enhances its protein stability via deubiquitination upon serum shock
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mice with a deletion of the Usp2 gene (Usp2 KO) display a longer free-running period of locomotor activity rhythms and altered responses of the clock to light