basic FUNCTION
| having ubiquitin thiolesterase activity |
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having a direct proapoptotic activity additionally tightening the connection between apoptosis and the ubiquitin-proteasome system |
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implicated as a novel positive regulator of TNF-induced NFKB signaling and show that its expression is altered in tumor cells |
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de-ubiquitinylates and stabilizes target proteins, is rhythmically expressed in multiple tissues including the SCN |
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potentially mediates circadian disruption by suppressing the CRY1 degradation during inflammation |
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role for the rhythmically-expressed deubiquitinating enzyme ubiquitin specific peptidase 2 (USP2) in clock function |