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FLASH GENE

Symbol

USP2

contributors: mct - updated : 12-01-2013

HGNC name	ubiquitin specific protease 2
HGNC id	12618

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	11q23.3      Physical location : 119.225.925 - 119.252.436
Synonym symbol(s)	UBP41, USP9
EC.number	3.4.19.12

DNA

TYPE	functioning gene
STRUCTURE	26.51 kb     13 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_004205 13 - 2748 NP_004196 - 605 - 2012 22659130 USP2a stabilizing fatty acid synthase (FAS), often overexpressed in biologically aggressive tumors(in prostate cancer) USP2a and USP2c, two isoforms of the ubiquitin-specific protease USP2, cause cell death upon ectopic expression NM_171997 13 - 3013 NP_741994 45 396 . localized to peroxisomes in hepatocytes through a canonical peroxisome-targeting motif at its C-terminus 2012 22659130 USP2b, (USP2-45) is a deubiquitinase that regulates hepatic gluconeogenesis and glucose metabolism is in a complex with several clock components and regulates the stability and turnover of ARNTL, which in turn alters the expression of several PER/ARNTL controlled genes NM_001243759 12 - 2933 NP_001230688 - 362 - 2012 22659130 USP2c USP2a and USP2c, two isoforms of the ubiquitin-specific protease USP2, cause cell death upon ectopic expression

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive esophagus       highly Endocrine parathyroid       highly Nervous nerve cranial nerve     highly Reproductive male system testis     highly Urinary kidney

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
	intracellular,nucleus
	intracellular,nuclear envelope

basic FUNCTION	having ubiquitin thiolesterase activity
	having a direct proapoptotic activity additionally tightening the connection between apoptosis and the ubiquitin-proteasome system
	implicated as a novel positive regulator of TNF-induced NFKB signaling and show that its expression is altered in tumor cells
	de-ubiquitinylates and stabilizes target proteins, is rhythmically expressed in multiple tissues including the SCN
	potentially mediates circadian disruption by suppressing the CRY1 degradation during inflammation
	role for the rhythmically-expressed deubiquitinating enzyme ubiquitin specific peptidase 2 (USP2) in clock function

CELLULAR PROCESS	cell life, cell death/apoptosis
	protein, degradation
	protein, ubiquitin dependent proteolysis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

new core component of the clock machinery and potential role for deubiquitination in the regulation of the circadian clock, both at the level of the core pacemaker and its response to external cues

INTERACTION

DNA

RNA

small molecule

protein	STUB1 and USP2 show antagonistic functions in the control of AIFM1-mediated cell death, and implicate the role of the enzymes as a switch for cells to live or die under stresses that cause truncated AIFM1 release
	mediates mitotic progression by regulating the stability of Aurora-A
	interacts with CRY1 and enhances its protein stability via deubiquitination upon serum shock

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

mice with a deletion of the Usp2 gene (Usp2 KO) display a longer free-running period of locomotor activity rhythms and altered responses of the clock to light