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FLASH GENE
Symbol IFIT1 contributors: mct - updated : 23-08-2014
HGNC name interferon-induced protein with tetratricopeptide repeats 1
HGNC id 5407
PROTEIN
PHYSICAL PROPERTIES Amphiphilic
STRUCTURE
motifs/domains
  • ten tetratricopeptide repeats (TPR) made of two interacting amphipathic alpha helices named domains A and D
  • secondary structure two alpha helices
    HOMOLOGY
    Homologene
    FAMILY IFI family
    CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • virus-induced protein associated with TMEM173, an adapter protein involved in virus-triggered induction of type I IFNs
  • mediator of negative-feedback regulation of virus-triggered induction of type I IFNs and cellular antiviral responses
  • antiviral protein that recognizes 5prime-triphosphate RNA, antagonizing viruses by sequestering specific viral nucleic acids
  • IFIT1 and IFITM1 serve as important molecules to restrict HCV infection, and they may have implications in the development of therapeutic modalities
  • IFIT1 and IFIT2 contribute significantly to the regulation of HBV replication, likely at both transcriptional and posttranscriptional steps
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction between IFIT1 and eukaryotic elongation factor-1A (EEF1A1)
  • IFIT1 bound PPP-RNA with nanomolar affinity and required the arginine at position 187 in a highly charged C-terminal groove of the protein
  • can directly recognize viral RNA bearing a 5 prime-triphosphate group (PPP-RNA), which is a molecular signature that distinguishes it from host RNA
  • binding to PPP-RNA is critical for the antiviral activity of IFIT1
  • positive feedback loop between phosphorylated STAT1 and IFIT1, IFIT2, IFIT3
  • more IRF8 bound to the IFN-stimulated response element of the IFIT1 gene than to those of the IFIT2 and the IFIT3 genes
  • cell & other
    REGULATION
    induced by interferon alpha-inducible
    interleukin 1,retinoic acid,viral infection
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS