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FLASH GENE
Symbol IFIT1 contributors: mct - updated : 23-08-2014
HGNC name interferon-induced protein with tetratricopeptide repeats 1
HGNC id 5407
DNA
TYPE functioning gene
STRUCTURE 11.42 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Map cen - D10S579 - D10S215 - D10S1765 - D10S541 - D10S1571 ,(IFIT2 - IFIT3 ) - D10S1442 - D10S1739 - IFIT1 - D10S1753 - D10S536 - D10S564 - D10S1755 - IDE ,D10S583 - D10S185 - D10S200 ,PDE6C ,RBP4 RBP4 - qter
Authors Gray (97), De Veer (98)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 1690 55.3 478 - Gravilov
2 - 1876 56 478 - Gravilov
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon  
Reproductivefemale systemuteruscervix highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES Amphiphilic
STRUCTURE
motifs/domains
  • ten tetratricopeptide repeats (TPR) made of two interacting amphipathic alpha helices named domains A and D
  • secondary structure two alpha helices
    HOMOLOGY
    Homologene
    FAMILY IFI family
    CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • virus-induced protein associated with TMEM173, an adapter protein involved in virus-triggered induction of type I IFNs
  • mediator of negative-feedback regulation of virus-triggered induction of type I IFNs and cellular antiviral responses
  • antiviral protein that recognizes 5prime-triphosphate RNA, antagonizing viruses by sequestering specific viral nucleic acids
  • IFIT1 and IFITM1 serve as important molecules to restrict HCV infection, and they may have implications in the development of therapeutic modalities
  • IFIT1 and IFIT2 contribute significantly to the regulation of HBV replication, likely at both transcriptional and posttranscriptional steps
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction between IFIT1 and eukaryotic elongation factor-1A (EEF1A1)
  • IFIT1 bound PPP-RNA with nanomolar affinity and required the arginine at position 187 in a highly charged C-terminal groove of the protein
  • can directly recognize viral RNA bearing a 5 prime-triphosphate group (PPP-RNA), which is a molecular signature that distinguishes it from host RNA
  • binding to PPP-RNA is critical for the antiviral activity of IFIT1
  • positive feedback loop between phosphorylated STAT1 and IFIT1, IFIT2, IFIT3
  • more IRF8 bound to the IFN-stimulated response element of the IFIT1 gene than to those of the IFIT2 and the IFIT3 genes
  • cell & other
    REGULATION
    induced by interferon alpha-inducible
    interleukin 1,retinoic acid,viral infection
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS