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FLASH GENE
Symbol GLG1 contributors: mct - updated : 11-04-2013
HGNC name golgi apparatus protein 1
HGNC id 4316
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • proline-glutamine rich intraluminal domain
  • 16 cysteine-rich repeats
  • a single transmembrane segment (TM1)
  • a short conserved cytoplasmic tail
  • C-terminal region retains GLG1 in the Golgi apparatus
    • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to rattus mg160 and Selel
    ortholog to murine Esl1 and Selel
    homolog to Xenopus Xl.7363
    homolog to Zebrafish Dr.12007
    homolog to Drosophila CG7190
    homolog to C.elegans F14E5.2
    Homologene
    FAMILY
    CATEGORY signaling growth factor , receptor
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text
  • type I membrane protein
  • its expression in the Golgi apparatus and on the plasma membrane is finely tuned through two distinct mechanisms for exhibiting different functions
    • basic FUNCTION
  • is the product of a single gene, the mRNA of which can be processed by alternative splicing to generate two different transcripts encoding either GLG1 or GLG2
  • GLG1, SELPLG and CD44 encompassed all endothelial-selectin ligand activity on neutrophils by using gene- and RNA-targeted loss of function
  • distinct and dynamic contributions of these three glycoproteins in selectin-mediated neutrophil adhesion and signaling
  • is involved in FGF18 signalling via FGFR3C
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to fibroblast growth factor and E selectin
  • novel regulatory mechanism for FGF18 signaling involving GLG1 and DLK1
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in low-grade astrocytomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS