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FLASH GENE

Symbol

GLG1

contributors: mct - updated : 11-04-2013

HGNC name	golgi apparatus protein 1
HGNC id	4316

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	16q23.1      Physical location : 74.481.327 - 74.641.042
Synonym name	membrane sialoglycoprotein of the Golgi apparatus
	cysteine-rich fibroblast growth factor receptor
	E-selectin ligand-1
Synonym symbol(s)	CFR-1, ESL-1, MG160 , MG-160

DNA

TYPE	functioning gene
STRUCTURE	159.72 kb     26 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001145666 26 - 8267 NP_001139138 - 1192 - 2005 15797922 NM_012201 27 - 8300 NP_036333 - 1203 - 2005 15797922 GLG1 GLG1 and GLG2 are the products of a single gene, the mRNA of which can be processed by alternative splicing to generate two different transcripts encoding either GLG1 or GLG2 NM_001145667 26 - 9339 NP_001139139 - 1179 - 2005 15797922 GLG2 - - - - 1227 - 2005 15797922 identical to GLG1 except with a unique 24-amino-acid extension at the C-terminus of its cytoplasmic domain GLG1 and GLG2 are the products of a single gene, the mRNA of which can be processed by alternative splicing to generate two different transcripts encoding either GLG1 or GLG2

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine thyroid       highly Reproductive female system ovary         male system testis     highly Respiratory respiratory tract trachea     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic granulocyte Homo sapiens Adult

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	proline-glutamine rich intraluminal domain
	16 cysteine-rich repeats
	a single transmembrane segment (TM1)
	a short conserved cytoplasmic tail
	C-terminal region retains GLG1 in the Golgi apparatus

conjugated

GlycoP

HOMOLOGY

interspecies	ortholog to rattus mg160 and Selel
	ortholog to murine Esl1 and Selel
	homolog to Xenopus Xl.7363
	homolog to Zebrafish Dr.12007
	homolog to Drosophila CG7190
	homolog to C.elegans F14E5.2

Homologene

FAMILY

CATEGORY

signaling growth factor , receptor

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm,organelle,lumen
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,Golgi
text	type I membrane protein
	its expression in the Golgi apparatus and on the plasma membrane is finely tuned through two distinct mechanisms for exhibiting different functions

basic FUNCTION	is the product of a single gene, the mRNA of which can be processed by alternative splicing to generate two different transcripts encoding either GLG1 or GLG2
	GLG1, SELPLG and CD44 encompassed all endothelial-selectin ligand activity on neutrophils by using gene- and RNA-targeted loss of function
	distinct and dynamic contributions of these three glycoproteins in selectin-mediated neutrophil adhesion and signaling
	is involved in FGF18 signalling via FGFR3C

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	binding to fibroblast growth factor and E selectin
	novel regulatory mechanism for FGF18 signaling involving GLG1 and DLK1

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in low-grade astrocytomas

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS