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FLASH GENE
Symbol HAAO contributors: mct - updated : 19-03-2019
HGNC name 3-hydroxyanthranilate 3,4-dioxygenase
HGNC id 4796
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer monomer
HOMOLOGY
interspecies homolog to murine Haao (86.3 pc)
homolog to rattus Haao (87.4 pc)
Homologene
FAMILY
  • 3-HAO family
    • CATEGORY enzyme , transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • catalyzing the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizing to quinolinate
  • acting as an electron carrier
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism cofactor
    signaling
    cofactor biosynthesis (NAD(+) biosynthesis; pyridine-2,3-dicarboxylate from L-kynurenine: step 3/3)
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, cofactor,
  • Fe2+
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to hypospadias
    Variant & Polymorphism SNP
  • rs3816183 of HAAO was significantly associated with susceptibility to hypospadias in general
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS