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FLASH GENE
Symbol HAAO contributors: mct - updated : 19-03-2019
HGNC name 3-hydroxyanthranilate 3,4-dioxygenase
HGNC id 4796
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervouscentral   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer monomer
HOMOLOGY
interspecies homolog to murine Haao (86.3 pc)
homolog to rattus Haao (87.4 pc)
Homologene
FAMILY
  • 3-HAO family
    • CATEGORY enzyme , transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • catalyzing the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizing to quinolinate
  • acting as an electron carrier
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism cofactor
    signaling
    cofactor biosynthesis (NAD(+) biosynthesis; pyridine-2,3-dicarboxylate from L-kynurenine: step 3/3)
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, cofactor,
  • Fe2+
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to hypospadias
    Variant & Polymorphism SNP
  • rs3816183 of HAAO was significantly associated with susceptibility to hypospadias in general
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS