SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,cytosolic
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| intracellular,nucleus,nucleoplasm
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| intracellular,nucleus,nucleolus
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| text
| dispersed throughout the cell during late mitosis and localized in nucleolus during interphase, confirming that the activity of DNAJC6 is regulated by its cell cycle specific expression together with its differential subcellular localization  |
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nuclear localization of DNAJB6 is associated with longer survival times of patients with esophageal squamous cell carcinoma |
| basic FUNCTION
| playing a role in oligomeric protein complex assembly |
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playing a role in polyglutamine aggregation in specific neurons |
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having a heat shock protein activity |
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might exert fundamental functions in reproduction |
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implicated in diverse cellular functions including placental development and inhibition of Huntingtin mediated cytotoxicity |
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with DNAJB8 are superior suppressors of aggregation and toxicity of disease-associated polyglutamine proteins |
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may play a role in maintaining an epithelial phenotype, and inhibition of the Wnt/beta-catenin pathway may be one of the potential mechanisms contributing to the restriction of malignant behavior by DNAJB6 |
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important involvement of DNAJB6, a member of heat-shock protein 40 (HSP40) family, in negatively impacting tumor growth |
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DNAJB6 and DNAJB8 protein chaperones prevent intracellular aggregation of polyglutamine peptides |
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is a peptide-binding chaperone that can interact with polyQ peptides that are incompletely degraded by and released from the proteasome |
