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Symbol DNAJB6 contributors: mct - updated : 04-12-2017
HGNC name DnaJ (Hsp40) homolog, subfamily B, member 6
HGNC id 14888
TYPE functioning gene
STRUCTURE 80.42 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC392156 7 similar to ppg3 DPP6 7q dipeptidylpeptidase 6 PAXIP1L 7q36.3 PAX transcription activation domain interacting protein 1 like HTR5A 7q36.1 5-hydroxytryptamine (serotonin) receptor 5A LOC389601 7 LOC389601 INSIG1 7q36 insulin induced gene 1 EN2 7q36.2 engrailed homolog 2 LOC392157 7 similar to RIKEN cDNA 9630008K15 gene MGC20460 7q36.3 hypothetical protein MGC20460 SHH 7q36 sonic hedgehog homolog (Drosophila) LOC389602 7 hypothetical gene supported by AK124321 LOC346305 7q36.3 similar to hypothetical protein Tb927.2.4050 LOC285890 7q36.3 hypothetical LOC285890 C7orf13 7q36 chromosome 7 open reading frame 13 RNF32 7q36 ring finger protein 32 C7orf2 7q36 chromosome 7 open reading frame 2 C7orf3 7q36 chromosome 7 open reading frame 3 HLXB9 7q36 homeo box HB9 LOC392158 7 similar to S-adenosylmethionine decarboxylase KIAA0010 7q36.3 ubiquitin-protein isopeptide ligase (E3) DNAJB6 7q36.3 DnaJ (Hsp40) homolog, subfamily B, member 6 LOC392159 7 similar to polycystic kidney disease 1-like 3 LOC389603 7 hypothetical gene supported by AK098637 PTPRN2 7q36 protein tyrosine phosphatase, receptor type, N polypeptide 2 LOC285872 7q36.3 hypothetical gene supported by AL833137 FLJ20311 7q36.3 hypothetical protein FLJ20311 KIAA1228 7q36.3 hypothetical protein FLJ20311 FLJ10300 7q36.3 hypothetical protein FLJ10300 LOC392160 7 LOC392160 LOC392161 7 LOC392161 VIPR2 7q36.3 vasoactive intestinal peptide receptor 2 LOC154822 7q36.3 hypothetical protein LOC154822 LOC392162 7 similar to 68 kDa type I phosphatidylinositol-4-phosphate 5-kinase alpha
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 splicing 2494 36.1 326 - 2010 20522561
  • DNAJB6A, also called MRJ(L)
  • can act as a nuclear protein by virtue of its nuclear localization signal and can considerably reduce the expression of several secreted proteins that promote invasion, migration, and metastasis of cancer cells
  • inhibits Wnt/beta-catenin signaling by up-regulating DKK1, a secreted inhibitor of Wnt signaling
  • contains a nuclear localization signal and regulates CTNNB1 signaling during breast cancer developmen
  • 8 splicing 1568 26.9 241 - 2010 20522561
  • DNAJB6B also called MRJ(S), DNAJB6(S)
  • regulate keratin8/k18 organization
  • assist in NFATc3-mediated transcriptional repression
  • play a critical role in Huntington disease
  • having a cytoprotective effects that may be mediated, at least in part, by the mitochondrial pathway of apoptosis
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Nervousbrain   predominantly Homo sapiens
    Reproductivemale systemprostate  moderately
    Respiratorylung   moderately
    Urinarykidney   highly
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    cell lineage
    cell lines
    fluid/secretion sperm
    at STAGE
  • a J domain
  • a conserved G/F domain, mediating chaperone-substrate interactions in a manner that extends beyond recognition of a particular client and to a subset of client conformers
    interspecies ortholog to murine Dnajb6
  • DNAJ protein family
  • heat-shock protein 40 (HSP40) family
  • CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
  • dispersed throughout the cell during late mitosis and localized in nucleolus during interphase, confirming that the activity of DNAJC6 is regulated by its cell cycle specific expression together with its differential subcellular localization
  • nuclear localization of DNAJB6 is associated with longer survival times of patients with esophageal squamous cell carcinoma
  • basic FUNCTION
  • playing a role in oligomeric protein complex assembly
  • playing a role in polyglutamine aggregation in specific neurons
  • having a heat shock protein activity
  • might exert fundamental functions in reproduction
  • implicated in diverse cellular functions including placental development and inhibition of Huntingtin mediated cytotoxicity
  • with DNAJB8 are superior suppressors of aggregation and toxicity of disease-associated polyglutamine proteins
  • may play a role in maintaining an epithelial phenotype, and inhibition of the Wnt/beta-catenin pathway may be one of the potential mechanisms contributing to the restriction of malignant behavior by DNAJB6
  • important involvement of DNAJB6, a member of heat-shock protein 40 (HSP40) family, in negatively impacting tumor growth
  • DNAJB6 and DNAJB8 protein chaperones prevent intracellular aggregation of polyglutamine peptides
  • is a peptide-binding chaperone that can interact with polyQ peptides that are incompletely degraded by and released from the proteasome
  • CELLULAR PROCESS protein, post translation, folding
    a component
    small molecule
  • binding to PTTG
  • interacting with CFTR
  • interact with keratin intermediate filaments
  • J domain of DNAJB6 is involved in mediating SPP1 suppression
  • DNAJB6 binds HSPA8 and causes dephosphorylation of GSK3B at Ser 9 by recruiting protein phosphatase, PPP2CA
  • regulatory mechanism of DNAJB6-mediated DKK1 transcriptional up-regulation that can influence EMT (epithelial-mesenchymal transition)
  • interactions between PLAUR and HSPA4/DNAJB6 having functions in cell adhesion and migration that may provide more understanding of the roles in regulating cancer metastasis
  • inhibits the conversion of soluble polyQ peptides into amyloid fibrils, in particular by suppressing primary nucleation
  • DNAJB6 and HSPA4 cooperate to suppress SNCA aggregation
  • cell & other
    corresponding disease(s) LGMD1D
    Variant & Polymorphism
    Candidate gene
    Therapy target