Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CHST14 contributors: mct/npt - updated : 21-12-2009
HGNC name carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14
HGNC id 24464
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a 43-amino acid cytoplasmic domain
  • a 316-amino acid luminal domain
  • two potential N-linked glycosylation sites
    • HOMOLOGY
    interspecies homolog to Drosophila CG7015
    intraspecies homolog to HNK-1 sulfotransferase
    Homologene
    FAMILY
  • type II membrane protein family
  • sulfotransferase 2 family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text type 2 membrane protein
    basic FUNCTION
  • transfering sulfate to the C-4 hydroxyl of beta1,4-linked GalNAc that is substituted with an alpha-linked iduronic acid (IdoUA) at the C-3 hydroxyl
  • having specificity with predominant preference for IdoUA-GalNAc flanked by GlcUA-GalNAc over IdoUA-GalNAc flanked by IdoUA-GalNAc in exhaustively desulfated dermatan (Mikami 2003)
  • role in development and extracellular-matrix maintenance (Dundar 2009)
  • transfers active sulfate from 3'-phosphoadenosine 5'-phosphosulfate to position 4 of the N-acetyl-D-galactosamine (GalNAc) residues of dermatan sulfate (DS)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ATCS
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS