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FLASH GENE
Symbol RAB28 contributors: mct - updated : 16-09-2013
HGNC name RAB28, member RAS oncogene family
HGNC id 9768
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated LipoP , Other
HOMOLOGY
interspecies homolog to Drosophila EG:80H7.4
homolog to C.elegans 4R79.2
homolog to C.elegans Y11D7A.4
Homologene
FAMILY
  • small GTPase superfamily
  • Rab family
    • CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    text
  • localization of RAB28 to the basal body and the ciliary rootlet of the photoreceptors
    • basic FUNCTION
  • involved in vesicle transport
  • GTPase activity
  • essential regulator of membrane trafficking
  • coordinates potentially the activity of retromer-dependent trafficking and ESCRT-mediated degradative pathways
  • regulator of NFKB1 nuclear transport, might participate in the disturbance of EC (endothelial cells) homeostasis
  • might be involved in ciliary transport in photoreceptor cells
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • GTP
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CORD28
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS