Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol RAB28 contributors: mct - updated : 16-09-2013
HGNC name RAB28, member RAS oncogene family
HGNC id 9768
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   lowly Homo sapiens
Nervousbrain   predominantly Homo sapiens
Reproductivemale systemtestis  predominantly Homo sapiens
Visualeyeretina    Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal lowly Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Visualcone photoreceptor Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated LipoP , Other
HOMOLOGY
interspecies homolog to Drosophila EG:80H7.4
homolog to C.elegans 4R79.2
homolog to C.elegans Y11D7A.4
Homologene
FAMILY
  • small GTPase superfamily
  • Rab family
    • CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    text
  • localization of RAB28 to the basal body and the ciliary rootlet of the photoreceptors
    • basic FUNCTION
  • involved in vesicle transport
  • GTPase activity
  • essential regulator of membrane trafficking
  • coordinates potentially the activity of retromer-dependent trafficking and ESCRT-mediated degradative pathways
  • regulator of NFKB1 nuclear transport, might participate in the disturbance of EC (endothelial cells) homeostasis
  • might be involved in ciliary transport in photoreceptor cells
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • GTP
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CORD28
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS