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FLASH GENE
Symbol RAB17 contributors: mct - updated : 07-09-2011
HGNC name RAB17, member RAS oncogene family
HGNC id 16523
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated LipoP , Other
HOMOLOGY
Homologene
FAMILY
  • small GTPase superfamily
  • Rab family
    • CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,endosome
    text
  • basolateral plasma membrane ; apical tubules
  • localized at dendritic growth cones, shafts, filopodia, and mature spines, but it is mostly absent in axons
  • in neuronal dendrites is localized at recycling/early endosomes
    • basic FUNCTION
  • involved in intracellular transport
  • acts on melanosomes downstream of RAB27A
  • new functions for recycling endosome and RAB17 in pigmentation through a distal step in the process of melanosome release via filopodia
  • mediates dendrite growth and branching and it does not regulate axon growth or branching
  • plays a crucial role in dendritic morphogenesis in hippocampal neurons
  • is necessary for the formation of dendritic filopodia
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text protein transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • GTP
    • protein
    cell & other
    REGULATION
    Other induced during cell polarization (differentiation)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS