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FLASH GENE

Symbol

RAB17

contributors: mct - updated : 07-09-2011

HGNC name	RAB17, member RAS oncogene family
HGNC id	16523

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic thymus       highly Endocrine pancreas         Nervous brain limbic system hippocampus     Mus musculus Reproductive male system prostate       Respiratory lung         Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine

cells

System Cell Pubmed Species Stage Rna symbol   epithelial cell Nervous neuron Mus musculus

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

conjugated

LipoP , Other

HOMOLOGY

Homologene

FAMILY	small GTPase superfamily
	Rab family

CATEGORY

protooncogene

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,endosome
text	basolateral plasma membrane ; apical tubules
	localized at dendritic growth cones, shafts, filopodia, and mature spines, but it is mostly absent in axons
	in neuronal dendrites is localized at recycling/early endosomes

basic FUNCTION	involved in intracellular transport
	acts on melanosomes downstream of RAB27A
	new functions for recycling endosome and RAB17 in pigmentation through a distal step in the process of melanosome release via filopodia
	mediates dendrite growth and branching and it does not regulate axon growth or branching
	plays a crucial role in dendritic morphogenesis in hippocampal neurons
	is necessary for the formation of dendritic filopodia

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

text	protein transport

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	nucleotide,
	GTP

protein

cell & other

REGULATION

Other

induced during cell polarization (differentiation)

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS