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FLASH GENE

Symbol

THOC5

contributors: mct/npt - updated : 21-03-2009

HGNC name	THO complex 5
HGNC id	19074

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a nuclear localization signal (NLS)
	two LxxLL motifs
	a putative PEST domain

HOMOLOGY

interspecies

homolog to murine Fmip

Homologene

FAMILY

CATEGORY

signaling growth factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus
text	nuclear localization governed by protein kinase C-mediated phosphorylation (Mancini 2004)

basic FUNCTION	affecting granulocyte/macrophage differentiation
	playing a role in cytokine-stimulated monocytic development (Carney 2009)
	can potentiate receptor signaling to transcription factor expression and monocyte differentiation (Carney 2009)
	spliceosome protein, target in macrophage colony-stimulating factor signalling that is involved in the regulation of transcription factor expression (Pierce 2008)
	target for modulation of signal transduction with a potential role in leukaemogenesis (Pierce 2008)
	nucleocytoplasmic shuttling protein (El Bounkari 2009)

CELLULAR PROCESS	cell life, differentiation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	member of the spliceosome complex which potentiates C/EBP expression in adipocyte differentiation (Carney 2009)
	member of the THO complex that associate with the mRNA export apparatus (El Bounkari 2009)

INTERACTION

DNA

RNA

small molecule

protein	interacting with CSF1R (couples CSF1 receptor signaling to transcription factor expression) (Carney 2009)
	interacting with THOC7 (THOC7/THOC5 interaction is required for nuclear localization of THOC7) (El Bounkari 2009)

cell & other

REGULATION

Other

phosphorylated on tyrosine by Fms tyrosine kinase (Mancini 2004)

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS