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FLASH GENE
Symbol THOC5 contributors: mct/npt - updated : 21-03-2009
HGNC name THO complex 5
HGNC id 19074
DNA
TYPE functioning gene
STRUCTURE 45.58 kb     20 Exon(s)
MAPPING cloned Y linked N status provisional
regionally located located in the NF2/meningioma region
RNA
TRANSCRIPTS type messenger
text four variants encode the same protein
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
21 - 2694 78 683 - El Bounkari (2009)
20 - 2578 - 683 - El Bounkari (2009)
21 - 2563 - 683 - El Bounkari (2009)
20 - 2447 - 683 - El Bounkari (2009)
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticneutrophil
Blood/Hematopoieticprogenitor cell
Lymphoid/Immunemacrophage
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a nuclear localization signal (NLS)
  • two LxxLL motifs
  • a putative PEST domain
    • HOMOLOGY
    interspecies homolog to murine Fmip
    Homologene
    FAMILY
    CATEGORY signaling growth factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text nuclear localization governed by protein kinase C-mediated phosphorylation (Mancini 2004)
    basic FUNCTION
  • affecting granulocyte/macrophage differentiation
  • playing a role in cytokine-stimulated monocytic development (Carney 2009)
  • can potentiate receptor signaling to transcription factor expression and monocyte differentiation (Carney 2009)
  • spliceosome protein, target in macrophage colony-stimulating factor signalling that is involved in the regulation of transcription factor expression (Pierce 2008)
  • target for modulation of signal transduction with a potential role in leukaemogenesis (Pierce 2008)
  • nucleocytoplasmic shuttling protein (El Bounkari 2009)
    • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • member of the spliceosome complex which potentiates C/EBP expression in adipocyte differentiation (Carney 2009)
  • member of the THO complex that associate with the mRNA export apparatus (El Bounkari 2009)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with CSF1R (couples CSF1 receptor signaling to transcription factor expression) (Carney 2009)
  • interacting with THOC7 (THOC7/THOC5 interaction is required for nuclear localization of THOC7) (El Bounkari 2009)
    • cell & other
    REGULATION
    Other phosphorylated on tyrosine by Fms tyrosine kinase (Mancini 2004)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS