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FLASH GENE

Symbol

RNF38

contributors: mct - updated : 07-12-2013

HGNC name	ring finger protein 38
HGNC id	18052

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a coiled coil motif and a RING zinc finger of the C3H2C2 (RING-H2 finger) type at the C terminus

conjugated

MetalloP

HOMOLOGY

interspecies

ortholog to rattus OIP1

Homologene

FAMILY

RING zinc finger protein family

CATEGORY

regulatory , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,chromatin/chromosome

basic FUNCTION	acting as a negative coregulator for LIM homeodomain transcription factors
	via the recruitment of the SIN3A/histone deacetylase corepressor complex
	functional ubiquitin protein ligase (E3)
	is an E3 ubiquitin ligase that may play a role in regulating TP53

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

complexing with LIM/homeobox factors

INTERACTION

DNA

binding

RNA

small molecule	metal binding,
	zinc Zn2+

protein

binding partner of TP53 and RNF38 can ubiquitinate TP53

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS