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FLASH GENE
Symbol RNF38 contributors: mct - updated : 07-12-2013
HGNC name ring finger protein 38
HGNC id 18052
DNA
TYPE functioning gene
STRUCTURE 65.00 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
regionally located 78kb centromeric to the CNE gene
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinethyroid    
Nervousbraindiencephalonamygdala  
 brainhindbrainmedulla oblongata  
Reproductivemale systemtestis  highly
Visualeyelacrimal gland   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a coiled coil motif and a RING zinc finger of the C3H2C2 (RING-H2 finger) type at the C terminus
conjugated MetalloP
HOMOLOGY
interspecies ortholog to rattus OIP1
Homologene
FAMILY RING zinc finger protein family
CATEGORY regulatory , transcription factor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus,chromatin/chromosome
basic FUNCTION
  • acting as a negative coregulator for LIM homeodomain transcription factors
  • via the recruitment of the SIN3A/histone deacetylase corepressor complex
  • functional ubiquitin protein ligase (E3)
  • is an E3 ubiquitin ligase that may play a role in regulating TP53
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component complexing with LIM/homeobox factors
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
    zinc Zn2+
    protein
  • binding partner of TP53 and RNF38 can ubiquitinate TP53
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS