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FLASH GENE

Symbol

DHX8

contributors: mct - updated : 27-02-2020

HGNC name	DEAH (Asp-Glu-Ala-His) box polypeptide 8
HGNC id	2749

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a N terminal DEAD/H (Asp-Glu-Ala-Asp/His) domain
	a C terminal helicase domain
	a nuclear localization signal (NLS)
	a RS domain (serine rich domain)

HOMOLOGY

interspecies	ortholog to yeast S.cerevisiae Prp22
	homolog to murine Ddx8
	homolog to Drosophila CG8241
	homolog to C.elegans mog-5

Homologene

FAMILY

DEAD/H box family, DEAH subfamily

CATEGORY

enzyme , RNA associated , transport

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria
	intracellular,nucleus,nucleoplasm,nuclear bodies
text	transport to nucleus dependent on active RNA POL II transcription

basic FUNCTION	releasing of spliced mRNA from the spliceosome
	putative RNA helicase with RNA dependent ATPase
	is a crucial component of the eukaryotic pre-mRNA splicing machinery
	cellular complexes comprising CACTIN, DHX8 and SRRM2 sustain precise chromosome segregation, genome stability and cell proliferation by allowing faithful splicing of specific pre-mRNAs
	is a crucial DEAH-box RNA helicase involved in splicing and required for the release of mature mRNA from the spliceosome

CELLULAR PROCESS

nucleotide, RNA splicing

PHYSIOLOGICAL PROCESS

cellular trafficking transport

text	nuclear export of spliced mRNA

PATHWAY

metabolism

signaling

a component

spliceosome complex

INTERACTION

DNA

RNA

binding

small molecule	nucleotide,
	ATP

protein	SNW1-associated factors DHX8 and PRPF19 are also selectively required for CDKN1A expression under stress
	CACTIN physically and functionally interacts with the spliceosome-associated factors DHX8 and SRRM2

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS