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FLASH GENE
Symbol RNPS1 contributors: mct - updated : 26-01-2013
HGNC name RNA binding protein S1, serine-rich domain
HGNC id 10080
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • long N terminal serine-rich (SR) region, and with ACIN1, contain typical motifs of splicing regulatory proteins including arginine/serine-rich domains
  • 90 AA RRM containing RNP1 and RNP2 submotifs
  • two ARG rich RNA binding domain
  • C terminal nuclear localization signal (NLS)
    • HOMOLOGY
    interspecies homolog to murine Rnps1
    Homologene
    FAMILY
  • splicing factor SR family
    • CATEGORY regulatory , RNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    basic FUNCTION
  • involved in the regulation of splicing or transcription, communicating the position of exon -exon junctions to the mRNA surveillance machinery
  • cellular concentrations of RNPS1 can modify nonsense-mediated mRNA decay efficiency and cell type specific co-factor availability represents a novel principle that controls nonsense-mediated mRNA decay
  • is able to function together with ASF/SF2 to form RNP complexes on nascent transcripts, and thereby prevent formation of transcriptional R-loops
  • both RNPS1 and, surprisingly, SAP18 strongly modulated splicing regulation
    • CELLULAR PROCESS nucleotide, transcription
    nucleotide, RNA splicing
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the post splicing multiprotein complex involved in mRNA nuclear export and mRNA surveillance for the detection of truncated messengers ans initiation of nonsense mediated mRNA decay
  • component of the exon junction complex
  • RNPS1, ACIN1, and SAP18 form the apoptosis- and splicing-associated protein (ASAP) complex, which is also part of the exon junction complex
    • INTERACTION
    DNA S-phase prevalent DNA binding protein
    RNA
    small molecule
    protein
  • PITSLRE
  • ZFR
  • ACIN1 is not required for nuclear localization and interaction of the other ASAP subunits SAP18 and RNPS1
  • SAP18 assembles a nuclear speckle-localized splicing regulatory multiprotein complex including RNPS1 and ACIN1 via its ubiquitin-like fold
  • PNN physically interacts with RNPS1 and SAP18, forming an alternative ternary complex, PSAP
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS