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FLASH GENE
Symbol RNPS1 contributors: mct - updated : 26-01-2013
HGNC name RNA binding protein S1, serine-rich domain
HGNC id 10080
Location 16p13.3      Physical location : 2.303.120 - 2.318.114
Synonym name
  • SR protein
  • S-phase prevalent DNA/RNA binding protein, murine homolog
  • SR-related protein LDC2
    • Synonym symbol(s) E5.1, MGC117332, LDC2, RNPS
    DNA
    TYPE functioning gene
    STRUCTURE 15.31 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 2095 34.2 305 - 1999 10449421
    8 - 2258 34.2 305 - 1999 10449421
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   highly
     stomach   highly
    Nervousbrain    
    Reproductivemale systemprostate  highly
    Respiratoryrespiratory tractlarynx  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • long N terminal serine-rich (SR) region, and with ACIN1, contain typical motifs of splicing regulatory proteins including arginine/serine-rich domains
  • 90 AA RRM containing RNP1 and RNP2 submotifs
  • two ARG rich RNA binding domain
  • C terminal nuclear localization signal (NLS)
    • HOMOLOGY
    interspecies homolog to murine Rnps1
    Homologene
    FAMILY
  • splicing factor SR family
    • CATEGORY regulatory , RNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    basic FUNCTION
  • involved in the regulation of splicing or transcription, communicating the position of exon -exon junctions to the mRNA surveillance machinery
  • cellular concentrations of RNPS1 can modify nonsense-mediated mRNA decay efficiency and cell type specific co-factor availability represents a novel principle that controls nonsense-mediated mRNA decay
  • is able to function together with ASF/SF2 to form RNP complexes on nascent transcripts, and thereby prevent formation of transcriptional R-loops
  • both RNPS1 and, surprisingly, SAP18 strongly modulated splicing regulation
    • CELLULAR PROCESS nucleotide, transcription
    nucleotide, RNA splicing
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the post splicing multiprotein complex involved in mRNA nuclear export and mRNA surveillance for the detection of truncated messengers ans initiation of nonsense mediated mRNA decay
  • component of the exon junction complex
  • RNPS1, ACIN1, and SAP18 form the apoptosis- and splicing-associated protein (ASAP) complex, which is also part of the exon junction complex
    • INTERACTION
    DNA S-phase prevalent DNA binding protein
    RNA
    small molecule
    protein
  • PITSLRE
  • ZFR
  • ACIN1 is not required for nuclear localization and interaction of the other ASAP subunits SAP18 and RNPS1
  • SAP18 assembles a nuclear speckle-localized splicing regulatory multiprotein complex including RNPS1 and ACIN1 via its ubiquitin-like fold
  • PNN physically interacts with RNPS1 and SAP18, forming an alternative ternary complex, PSAP
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS