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FLASH GENE
Symbol PRLHR contributors: - updated : 17-03-2006
HGNC name prolactin releasing hormone receptor
HGNC id 4464
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP
HOMOLOGY
interspecies ortholog to Chimpanzee GPR10
ortholog to murine Prlhr
ortholog to rattus Gpr10
intraspecies homolog to NPYR1
homolog to NPY2R
Homologene
FAMILY G protein coupled receptor 1 family
CATEGORY signaling , receptor membrane G
SUBCELLULAR LOCALIZATION     plasma membrane
basic FUNCTION
  • having neuropeptide Y receptor, rhodopsin-like receptor activities
  • implicated in the central control of lactation, appetite and blood pressure
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • receptor for NPY, PYY
  • cell & other
    REGULATION
    repressed by by bromocriptine (requiring CREB )
    Other regulated by forskolin
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    highly expressed in pheochromocytomas, suggesting potential pathophysiological roles of PrRP in these tumors
    Susceptibility to abnormal blood pressure
    Variant & Polymorphism other P305L associated with abnormal blood pressure
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • beginning at 16 weeks of age on a normal diet, mice lacking Prlhr overate, became obese, had increased body fat as well as leptin and insulin levels, and showed decreased glucose tolerance
  • Prlhr -/- mice had higher nociceptive thresholds and stronger stress-induced analgesia than wildtype mice, and that these differences could be suppressed by naloxone