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FLASH GENE
Symbol PRLHR contributors: - updated : 17-03-2006
HGNC name prolactin releasing hormone receptor
HGNC id 4464
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineadrenal gland    
 neuroendocrinepituitary  highly
nervousbraindiencephalon   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP
HOMOLOGY
interspecies ortholog to Chimpanzee GPR10
ortholog to murine Prlhr
ortholog to rattus Gpr10
intraspecies homolog to NPYR1
homolog to NPY2R
Homologene
FAMILY G protein coupled receptor 1 family
CATEGORY signaling , receptor membrane G
SUBCELLULAR LOCALIZATION     plasma membrane
basic FUNCTION
  • having neuropeptide Y receptor, rhodopsin-like receptor activities
  • implicated in the central control of lactation, appetite and blood pressure
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • receptor for NPY, PYY
  • cell & other
    REGULATION
    repressed by by bromocriptine (requiring CREB )
    Other regulated by forskolin
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    highly expressed in pheochromocytomas, suggesting potential pathophysiological roles of PrRP in these tumors
    Susceptibility to abnormal blood pressure
    Variant & Polymorphism other P305L associated with abnormal blood pressure
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • beginning at 16 weeks of age on a normal diet, mice lacking Prlhr overate, became obese, had increased body fat as well as leptin and insulin levels, and showed decreased glucose tolerance
  • Prlhr -/- mice had higher nociceptive thresholds and stronger stress-induced analgesia than wildtype mice, and that these differences could be suppressed by naloxone