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FLASH GENE

Symbol

PPP1R9B

contributors: mct/pgu - updated : 03-01-2012

HGNC name	protein phosphatase 1, regulatory subunit 9B, spinophilin
HGNC id	9298

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	properties expected of a scaffolding protein localized to the cell membrane and a single consensus sequence in PSD95/DLG/ZO-1
	a PDZ domain

HOMOLOGY

interspecies

homolog to C.elegans TO9A5.9

Homologene

FAMILY

CATEGORY

chaperone/stress , regulatory

SUBCELLULAR LOCALIZATION	plasma membrane,junction,adherens
	intracellular
	intracellular,cytoplasm,cytoskeleton
	intracellular,nucleus,nucleoplasm
text	dendritic spines

basic FUNCTION	modulating both glutamatergic synaptic transmission and dendritic morphology
	modulating PP1 enzymatic activity
	enhancing DCX binding to F-actin
	may be acting as a scaffold protein in multiple signaling pathways
	PPP1R19A, and PPP1R19B reciprocally regulate Ca(2+) signaling by GPCRs
	may play an important role in linking the actin cytoskeleton to the plasma membrane at the synaptic junction
	may play analogous roles in information transfer at both neuronal and immunological synapses.
	dendritic spine-enriched scaffold protein, modulating synaptic transmission via multiple functions mediated by distinct domains of the protein
	key modulator of opiate action
	potent physiological role in regulating OPRM1 function
	required for synapse formation in the NK cells, suggesting that it may be involved in the maintenance of cellular architecture by regulation of actin assembly
	regulates actin cytoskeletal organization and is required for hepatocyte growth factor-induced cell migration, in cooperation with SPATA13 and APC
	its expression could enhance the regulatory function of RGS8 on the CHRM3, but the acceleration function of RGS8 on the M2-mediated signaling could not be enhanced by PPP1R9B
	BAIAP2 and PPP1R9B regulate localized RAC1 activation by TIAM1

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	regulatory subunit of protein phosphatase-1 catalytic subunit
	PPP1R9B/PPP1R9A forms a functional pair of opposing regulators that modulates Ca(2+) signaling intensity by GPCRs by determining the extent of inhibition by the R4 family of RGS proteins

INTERACTION

DNA

RNA

small molecule

protein	actin, PP1, ARF (CDKN2A), playing a role in cell growth
	binds to actin filaments (f-actin) and shows cross-linking activity
	at the cellular level, spinophilin associates with OPRM1 in striatum and modulates OPRM1 signaling and endocytosis
	binds along the sides of the f-actin
	interacting with SPATA13
	PPP1R9B is a RGS8-interacting protein (CHRM1 and PPP1R9B compete for binding to RGS8)
	two TIAM1-interacting proteins in fibroblasts, insulin receptor substrate protein 53 kDa (BAIAP2) and PPP1R98B

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   combined loss of PPP1R9B and mutant TP53 activity led to increased mammary carcinomas

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed psychiatry     potential new target for the treatment of opiate addiction

ANIMAL & CELL MODELS

spinophilin knockout mice