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FLASH GENE
Symbol CELA3A contributors: np/ - updated : 16/12/2008
HGNC name chymotrypsin-like elastase family, member 3A
HGNC id 15944
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal peptide and propeptide of 28AA
  • 1 peptidase S1 domain
  • isoforms Precursor propeptide of 270AA and 29.5kDa
    HOMOLOGY
    intraspecies homolog to elastases I,elastases II
    paralog to ELA3B
    Homologene
    FAMILY
  • peptidase S1 family
  • elastase subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • serine proteases that hydrolyze many proteins
  • preferentially cleaves proteins after alanine residues
  • may possess not only a digestive function but also function(s) related to cholesterol metabolism or transport in the intestine
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS digestion
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    cholesterol metabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    expressed in pancreatic carcinoma cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS