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FLASH GENE
Symbol CELA3A contributors: np/ - updated : 16/12/2008
HGNC name chymotrypsin-like elastase family, member 3A
HGNC id 15944
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinepancreas   highly
Urinarybladder    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal peptide and propeptide of 28AA
  • 1 peptidase S1 domain
    • isoforms Precursor propeptide of 270AA and 29.5kDa
    HOMOLOGY
    intraspecies homolog to elastases I,elastases II
    paralog to ELA3B
    Homologene
    FAMILY
  • peptidase S1 family
  • elastase subfamily
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • serine proteases that hydrolyze many proteins
  • preferentially cleaves proteins after alanine residues
  • may possess not only a digestive function but also function(s) related to cholesterol metabolism or transport in the intestine
    • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS digestion
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    cholesterol metabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    expressed in pancreatic carcinoma cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS