protein
| importin-alpha subunit of the nuclear transport signal receptor  |
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Rad51  |
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p32 and p65 BRCA1 interacting proteins, cyclin A, cyclin B1, cyclin D1, cdc2, cdk2 and E2F  |
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BRAP2  |
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BAP1  |
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p53   |
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a component of the RNA polymerase II (Pol II) holoenzyme  |
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BRCA2  |
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c-Myc  |
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CtIP   |
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gamma-tubulin  |
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CtBP  |
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RbAp46 and RbAp48, HDAC1 and HDAC2  |
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hRad50-hMre11-p95 complex  |
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hypophosphorylated form of pRb  |
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CBP/p300  |
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BRCA1-associated genome surveillance complex: MSH2, MSH6, MLH1, ATM, BLM, and the RAD50-MRE11-NBS1 protein complex, and DNA replication factor C, RFC  |
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RNA polymerase II  |
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STAT1  |
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valosin-containing protein, VCP  |
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ZBRK1  |
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ATF1  |
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androgen receptor, AR and p160  |
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checkpoint kinase ATR  |
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JAK1 and JAK2  |
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FANCD2  |
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BACH1  |
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retinoblastoma suppressor (Rb)-associated protein 46, RbAp46  |
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c-Fos oncogene regulator Elk-1  |
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LMO4  |
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GADD45  |
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N-Myc-interacting protein, Nmi  |
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c-Abl  |
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JUNB and JUND  |
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alpha- and beta-tubulin  |
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Fanconi anemia protein, FANCA  |
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Acetyl Coenzyme A (CoA) Carboxylase alpha, ACCA  |
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ER-alpha  |
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Stat5a  |
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phosphatase 1alpha, PP1alpha  |
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Sp1  |
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p65/RelA  |
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four and a half LIM-only protein 2, FHL2  |
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BARD1/BRCC45/BRCC36  |
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IFI16  |
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p53  |
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Aurora-A  |
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FHL2  |
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zinc-finger-containing protein NUFIP  |
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nucleolar phosphoprotein nucleophosmin/B23, NPM  |
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SWI/SNF enzymes  |
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mitogen-activated protein kinase (MAPK) kinase kinase 3, MEKK3  |
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TRAP220  |
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Cdk-activating kinase, CAK  |
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Smad3 |
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hGCN5, TRRAP, and hMSH2/6  |
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poly(A)-binding protein 1, PABP  |
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cyclin D1  |
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Abraxas and RAP80  |
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TR-interacting protein, ATRIP  |
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CCDC98  |
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aryl hydrocarbon receptor, AhR  |
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ERK1/2  |
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p14ARF  |
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Ku80  |
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vitamin D receptor, VDR  |
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Rap80  |
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NBA1  |
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Mediator of Rap80 Interactions and Targeting 40 kd, MERIT40  |
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PALB2  |
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NINL ( |
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centrosomal protein Nlp  |
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E2s  |
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deleted in breast cancer 1, DBC1/KIAA1967  |
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FANCJ  |
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BRD7  |
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MRG15  |
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UBXN1  |
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HERC2  |
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UE2I  |
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TFII-I  |
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BCL2  |
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KIAA0101  |
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YY1 binds to the promoter of BRCA1, and its overexpression resulted in increased expression of BRCA1 and a number of BRCA1 downstream genes  |
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Cockayne syndrome B, CSB  |
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BARD1   |
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AP2-alpha, PAX2 and ZF5  |
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CDK1  |
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interaction between the breast/ovarian tumor suppressor gene BRCA1 and the transcription factor GATA3, an interaction, which is important for normal breast differentiation  |
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gamma tubulin, CRM1, and Aurora A  |
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BRCA1 antagonises TP53BP1-dependent DNA repair in S phase by inhibiting its interaction with chromatin proximal to damage sites  |
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claspin ( |
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loss of HSP90AA1 function abolishes BRCA1-dependent DSB repair  |
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SKP1 regulates BRCA1 protein stability  |
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FBXO44 is an important protein that influences BRCA1 protein level  |
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BRCA1 heterodimerizes with its partner protein, BARD1, via the RING domain present in both proteins  |
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BRCA1-dependent degradation of cyclin B and CDC25C is reversed by proteasome inhibitors and is enhanced following DNA damage, which may represent a possible mechanism to prevent cyclin B and CDC25C accumulation, a requirement for mitotic entry  |
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RBBP8 interacts with NBN and BRCA1, and connects CDK and ATM to regulate homologous recombination (HR)-mediated double-strand break repair  |
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ZNF423 appeared to be an estrogen-inducible BRCA1 transcription factor  |
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DCLRE1B is a nuclease required for efficient localization of the DNA repair proteins, FANCD2 and BRCA1  |
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BRCA1 downregulates the kinase activity of PLK1 by modulating the dynamic interactions of AURKA, BORA, and PLK1  |
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TP53BP1 recruitment requires the direct recognition of a DSB-specific histone code and its influence on pathway choice is mediated by mutual antagonism with BRCA1  |
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KDM5B is required for efficient DSB repair and for the recruitment of XRCC6 and BRCA1, the essential component of nonhomologous end-joining and homologous recombination, respectively  |
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FAM175A is a BRCA1 BRCT domain-interacting protein, playing a role in tumor suppression  |
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BRCA1 and BLM interact with RAD50 predominantly in S- and G2-phases, respectively  |
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functions as a bona fide tumor suppressor by regulating the protein stability and function of BRCA1 in breast cancer  |
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BRCA1 and BRIP1 cooperatively promote interstrand crosslinker induced centrosome amplification through the activation of PLK1  |
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gain of function mutant TP53 proteins cooperate with E2F4 to transcriptionally downregulate RAD17 and BRCA1 gene expression  |
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CEP72 is a novel BRCA1-interacting protein  |
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high levels of CEP72 counteract CHEK2 as a positive regulator of BRCA1 to ensure proper mitotic microtubule assembly  |
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BABAM1 is an essential component of the RAP80 ubiquitin recognition complex that targets BRCA1 to DNA damage sites  |
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mitotic function of BRCA1 depends on its phosphorylation by the tumor-suppressor kinase CHEK2 and this regulation is required to ensure normal microtubule plus end assembly rates within mitotic spindles  |
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dual molecular mechanism by which the CHEK2-BRCA1 axis restrains oncogenic AURKA activity during mitosis and BRCA1 itself is a target for AURKA relevant for chromosomal instability (CIN) |
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ERCC5 is a partner of BRCA1 and BRCA2 in maintaining genomic stability through homologous recombination (HRR)  |
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in cells, USP51 is recruited to chromatin after DNA damage and regulates the dynamic assembly/disassembly of TP53BP1 and BRCA1 foci  |
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BRCA1 (FANCS), MDC1, and RNF8 are required for BRCA2 (FANCD1) and SLX4 (FANCP) accumulation on the sex chromosomes during meiosis  |
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ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair  |
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ACLY phosphorylation and nuclear localization are necessary for its role in promoting BRCA1 recruitment  |
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both BRCA1 and BARD1 bind DNA and interact with RAD51, and BRCA1-BARD1 enhances the recombinase activity of RAD51  |
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FRK plays an important role in maintaining genomic stability, possibly in part through positively regulating BRCA1 protein stability and function via tyrosine phosphorylation on BRCA1 Tyr1552  |
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BRCA1 promotes oxidative metabolism by degrading POU2F1, a transcription factor with proglycolytic and tumorigenic effects  |
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regulation of BRCA1-BARD1 heterodimerization through SIRT2 deacetylation, elucidating a critical upstream signaling event directing BRCA1-BARD1 heterodimerization, which facilitates HR and tumor suppression  |
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novel function of the BRCA1-BARD1 complex in the regulation of TOP2B and Pol II-mediated gene expression  |